Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons.

Journal article

The activity of hypothalamic neurons that release the neuropeptides orexin-A and orexin-B is essential for normal wakefulness. Orexin neurons fire spontaneously and are hyperpolarized and inhibited by physiological neuromodulators, but the intrinsic determinants of their electrical activity are poorly understood. We show that mouse orexin neurons coexpress orexin-A and orexin-B, and possess a low-voltage-activated A-type K(+) current (A-current) likely to be composed of Kv4.3 subunits. The A-...

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Authors: Burdakov, D; Alexopoulos, H; Vincent, A; Ashcroft, F

• Publication status: Published
• Journal: European journal of neuroscience
• Volume: 20
• Issue: 12
• Pages: 3281-3285
• Publication date: 2004-12-01
• DOI: 10.1111/j.1460-9568.2004.03815.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Mice, Inbred C57BL; Action Potentials; Hypothalamus; Intracellular Signaling Peptides and Proteins; Animals; Male; 4-Aminopyridine; Neuropeptides; Mice; Potassium Channels; Electric Stimulation