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Germline genetic variants and risk of Barrett's esophagus and esophageal adenocarcinoma: a large scale meta-analysis of genome-wide association studies

Abstract:

Background

Esophageal adenocarcinoma (EA) is one of the fastest rising cancers in western countries. Barrett’s Esophagus (BE) is the premalignant precursor of EA. However, only a subset of BE patients develop EA, which complicates the clinical management in the absence of valid predictors. Genetic risk factors for BE and EA are incompletely understood. This study aimed to identify novel genetic risk factors for BE and EA.

Methods

Within an international consortium ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1016/S1470-2045(16)30240-6

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Tomlinson, I More by this author
Chegwidden, L More by this author
Gharahkhani, P More by this author
MacGregor, S More by this author
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US National Cancer Institute More from this funder
US National Institutes of Health More from this funder
National Health and Medical Research Council of Australia More from this funder
Swedish Cancer Society More from this funder
Medical Research Council More from this funder
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Publisher:
Elsevier: Lancet Publisher's website
Journal:
Lancet Oncology Journal website
Volume:
17
Issue:
10
Pages:
1363–1373
Publication date:
2016-08-05
Acceptance date:
2016-06-07
DOI:
ISSN:
1474-5488
URN:
uuid:8548bb60-25b3-4266-bbdc-8882cad4b253
Source identifiers:
633476
Local pid:
pubs:633476

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