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Dual contributions of noradrenaline to behavioural flexibility and motivation

Abstract:
Introduction While several theories have highlighted the importance of the noradrenergic system for behavioral flexibility, a number of recent studies have also shown a role for noradrenaline in motivation, particularly in effort processing. Here, we designed a novel sequential cost/benefit decision task to test the causal influence of noradrenaline on these two functions in rhesus monkeys. Methods We manipulated noradrenaline using clonidine, an alpha-2 nor... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s00213-018-4963-z

Authors


Gilardeau, S More by this author
Varazzani, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Experimental Psychology
Oxford college:
Oriel College
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Publisher:
Springer Verlag Publisher's website
Journal:
Psychopharmacology Journal website
Volume:
235
Issue:
9
Pages:
2687–2702
Publication date:
2018-07-11
Acceptance date:
2018-06-25
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Pubs id:
pubs:864371
URN:
uri:85482471-7799-401e-bef1-0c493472c916
UUID:
uuid:85482471-7799-401e-bef1-0c493472c916
Local pid:
pubs:864371

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