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Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome.

Abstract:

In a model of autosomally recessive Alport syndrome, mice that lack the alpha3 chain of collagen IV (Col4alpha3(-/-)) develop progressive glomerular damage leading to renal failure. The proposed mechanism is that podocytes fail to synthesize normal glomerular basement membrane, so the collagen IV network is unstable and easily degraded. We used this model to study whether bone marrow (BM) transplantation can rectify this podocyte defect by correcting the deficiency in Col4alpha3. Female C57BL...

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Publication status:
Published

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Publisher copy:
10.1634/stemcells.2006-0201

Authors


Prodromidi, EI More by this author
Poulsom, R More by this author
Jeffery, R More by this author
Roufosse, CA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Stem cells (Dayton, Ohio)
Volume:
24
Issue:
11
Pages:
2448-2455
Publication date:
2006-11-05
DOI:
EISSN:
1549-4918
ISSN:
1066-5099
URN:
uuid:85422f9d-e057-45c4-974e-0d49403d383f
Source identifiers:
95755
Local pid:
pubs:95755

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