- Abstract:
-
Ribonuclease H2 (RNase H2) is the major nuclear enzyme involved in the degradation of RNA/DNA hybrids and removal of ribonucleotides misincorporated in genomic DNA. Mutations in each of the three RNase H2 subunits have been implicated in a human auto-inflammatory disorder, Aicardi-Goutières Syndrome (AGS). To understand how mutations impact on RNase H2 function we determined the crystal structure of the human heterotrimer. In doing so, we correct several key regions of the previously reported...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m110.177394
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 286
- Issue:
- 12
- Pages:
- 10530-10539
- Publication date:
- 2011-03-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:853a2537-fe9c-464a-a391-1ca0337f7c1a
- Source identifiers:
-
107075
- Local pid:
- pubs:107075
- Copyright date:
- 2011
Journal article
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.
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