Journal article
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.
- Abstract:
-
Ribonuclease H2 (RNase H2) is the major nuclear enzyme involved in the degradation of RNA/DNA hybrids and removal of ribonucleotides misincorporated in genomic DNA. Mutations in each of the three RNase H2 subunits have been implicated in a human auto-inflammatory disorder, Aicardi-Goutières Syndrome (AGS). To understand how mutations impact on RNase H2 function we determined the crystal structure of the human heterotrimer. In doing so, we correct several key regions of the previously reported...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m110.177394
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 286
- Issue:
- 12
- Pages:
- 10530-10539
- Publication date:
- 2011-03-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
107075
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:107075
- UUID:
-
uuid:853a2537-fe9c-464a-a391-1ca0337f7c1a
- Local pid:
- pubs:107075
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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