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The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.

Abstract:

Ribonuclease H2 (RNase H2) is the major nuclear enzyme involved in the degradation of RNA/DNA hybrids and removal of ribonucleotides misincorporated in genomic DNA. Mutations in each of the three RNase H2 subunits have been implicated in a human auto-inflammatory disorder, Aicardi-Goutières Syndrome (AGS). To understand how mutations impact on RNase H2 function we determined the crystal structure of the human heterotrimer. In doing so, we correct several key regions of the previously reported...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.177394

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
12
Pages:
10530-10539
Publication date:
2011-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:853a2537-fe9c-464a-a391-1ca0337f7c1a
Source identifiers:
107075
Local pid:
pubs:107075

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