Journal article
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
- Abstract:
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BACKGROUND: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. METHODOLOGY: We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. T...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 137.5KB)
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- Publisher copy:
- 10.1371/journal.pone.0013950
Authors
Funding
National Institute of Child Health and Human Development
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Juvenile Diabetes Research Foundation International
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National Institute of Allergy and Infectious Diseases
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National Human Genome Research Institute
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National Institute on Aging
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 5
- Issue:
- 11
- Article number:
- e13950
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:115980
- UUID:
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uuid:85256cc1-6291-4b81-a1ca-c2001bf99b5c
- Local pid:
- pubs:115980
- Source identifiers:
-
115980
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Jones et al
- Copyright date:
- 2010
- Notes:
- Copyright 2010 Jones et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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