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Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Abstract:

Germline mutations in the tumour suppressor APC cause familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal cancers (CRCs). Hypermethylation of APC promoter 1A has been reported in a substantial proportion of sporadic CRCs and may cause transcriptional silencing. Methylation has been proposed as an alternative to mutation or loss of heterozygosity as a mechanism of gene inactivation. However, the significance of APC methylation has remained unclear, bec...

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Publication status:
Published

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Publisher copy:
10.1016/j.yexmp.2008.09.006

Authors


Segditsas, S More by this author
Sieber, OM More by this author
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Journal:
Experimental and molecular pathology
Volume:
85
Issue:
3
Pages:
201-206
Publication date:
2008-12-05
DOI:
EISSN:
1096-0945
ISSN:
0014-4800
URN:
uuid:851d9611-fef3-415f-84ca-6384a10e3e4c
Source identifiers:
72274
Local pid:
pubs:72274

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