Frequency and signature of somatic variants in 1461 human brain exomes
To systematically study somatic variants arising during development in the human brain across a spectrum of neurodegenerative disorders.
In this study we developed a pipeline to identify somatic variants from exome sequencing data in 1461 diseased and control human brains. Eighty-eight percent of the DNA samples were extracted from the cerebellum. Identified somatic variants were validated by targeted amplicon sequencin...Expand abstract
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