Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.

Journal article

OBJECTIVE: To study whether common genetic variants of the genes involved in the complex regulatory mechanism determining the intracellular bio-availability of T3 influence osteoarthritis onset. METHODS: In total 17 genetic variants within the genes encoding WD40-repeat/SOCS-box protein 1, ubiquitin specific protease 33, thyroid hormone receptor α, deiodinase, iodothyronine, type III (DIO3) and Indian hedgehog were measured and associated with osteoarthritis in a meta-analyses in European po...

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Authors: Meulenbelt, I; Bos, S; Chapman, K; van der Breggen, R; Houwing-Duistermaat, J

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 70
• Issue: 1
• Pages: 164-167
• Publication date: 2011-01-01
• DOI: 10.1136/ard.2010.133660
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Gene Frequency; Biological Availability; Middle Aged; Aged; Iodide Peroxidase; Genetic Predisposition to Disease; Osteoarthritis; Male; Female; Triiodothyronine; Polymorphism, Single Nucleotide; Humans