- Abstract:
-
5-Hydroxyuracil (5-OHU) in DNA, arising during endogenous DNA damage and caused by ionizing radiation, is removed by the base excision repair pathway. However, in addition to base lesions, ionizing radiation also generates DNA single-strand breaks (SSBs). When these DNA lesions are located in the proximity of each other, this may result in a profound effect on both repair of the damaged base and the SSB. We therefore examined the repair of DNA substrates containing 5-OHU lesions in the proxim...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi0622569
-
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- Journal:
- Biochemistry
- Volume:
- 46
- Issue:
- 13
- Pages:
- 4158-4163
- Publication date:
- 2007-04-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:85161ac9-8b46-4993-b204-1e0ad52b8630
- Source identifiers:
-
130958
- Local pid:
- pubs:130958
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
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