- Abstract:
-
Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We find that MRNIP is rapidly recruited to sites of DNA damage. Cells depleted of MRNIP...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.1mb)
-
- Publisher copy:
- 10.1016/j.celrep.2016.07.087
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell reports Journal website
- Volume:
- 16
- Issue:
- 10
- Pages:
- 2565-2575
- Publication date:
- 2016-08-25
- Acceptance date:
- 2016-07-27
- DOI:
- ISSN:
-
2211-1247
- Pubs id:
-
pubs:641091
- URN:
-
uri:8508ce80-b4a0-47a2-9272-960f12a51d91
- UUID:
-
uuid:8508ce80-b4a0-47a2-9272-960f12a51d91
- Local pid:
- pubs:641091
- Language:
- English
- Keywords:
- Copyright holder:
- Staples, et al.
- Copyright date:
- 2016
- Notes:
- © Staples, et al. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). This is the publisher's version of the article available online from Elsevier at: 10.1016/j.celrep.2016.07.087
Journal article
MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
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