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MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

Abstract:

Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We find that MRNIP is rapidly recruited to sites of DNA damage. Cells depleted of MRNIP...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2016.07.087

Authors


Staples, Christopher J. More by this author
Barone, Giancarlo More by this author
Myers, Katie N. More by this author
Ganesh, Anil More by this author
More by this author
Department:
Oxford, MSD, Pathology Dunn School
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Publisher:
Elsevier Publisher's website
Journal:
Cell reports Journal website
Volume:
16
Issue:
10
Pages:
2565-2575
Publication date:
2016-08-25
Acceptance date:
2016-07-27
DOI:
ISSN:
2211-1247
Pubs id:
pubs:641091
URN:
uri:8508ce80-b4a0-47a2-9272-960f12a51d91
UUID:
uuid:8508ce80-b4a0-47a2-9272-960f12a51d91
Local pid:
pubs:641091
Language:
English
Keywords:

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