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MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

Abstract:

Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We find that MRNIP is rapidly recruited to sites of DNA damage. Cells depleted of MRNIP...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.07.087

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Cell reports Journal website
Volume:
16
Issue:
10
Pages:
2565-2575
Publication date:
2016-08-25
Acceptance date:
2016-07-27
DOI:
ISSN:
2211-1247
Pmid:
27568553
Language:
English
Keywords:
Pubs id:
pubs:641091
UUID:
uuid:8508ce80-b4a0-47a2-9272-960f12a51d91
Local pid:
pubs:641091
Source identifiers:
641091
Deposit date:
2016-09-21

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