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Increasing endothelial cell specific expression by the use of heterologous hypoxic and cytokine-inducible enhancers.

Abstract:

One of the current challenges in gene therapy is to construct a vector that will target specific tissues. Targeting expression to endothelium is of particular interest in the treatment of several pathologies. We have shown previously that defined regions of the E-selectin and KDR promoters confer endothelial cell specific expression following retroviral delivery. However, the levels of expression were low. In an attempt to increase expression but to preserve the tissue specificity we have exa...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301177

Authors


Modlich, U More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Bicknell, R More by this author
Journal:
Gene therapy
Volume:
7
Issue:
10
Pages:
896-902
Publication date:
2000-05-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:850748a7-8198-4e4c-8ad8-15f8864f2a81
Source identifiers:
31692
Local pid:
pubs:31692

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