- Abstract:
-
The major components of the cartilage extracellular matrix are type II collagen and aggrecan. Type II collagen provides cartilage with its tensile strength, whereas the water-binding capacity of aggrecan provides compressibility and elasticity. Aggrecan breakdown leads to an increase in proteolytic susceptibility of articular collagen; hence, aggrecan may also have a protective effect on type II collagen. Given their role in aggrecan degradation and differing substrate specificity profiles, t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.ab.2007.09.014
-
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- Journal:
- Analytical biochemistry
- Volume:
- 373
- Issue:
- 1
- Pages:
- 43-51
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1096-0309
- ISSN:
-
0003-2697
- URN:
-
uuid:8503bdba-7888-4731-862a-236c6de3b339
- Source identifiers:
-
226974
- Local pid:
- pubs:226974
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
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