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Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.

Abstract:

The major components of the cartilage extracellular matrix are type II collagen and aggrecan. Type II collagen provides cartilage with its tensile strength, whereas the water-binding capacity of aggrecan provides compressibility and elasticity. Aggrecan breakdown leads to an increase in proteolytic susceptibility of articular collagen; hence, aggrecan may also have a protective effect on type II collagen. Given their role in aggrecan degradation and differing substrate specificity profiles, t...

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Publication status:
Published

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Publisher copy:
10.1016/j.ab.2007.09.014

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Journal:
Analytical biochemistry
Volume:
373
Issue:
1
Pages:
43-51
Publication date:
2008-02-05
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
URN:
uuid:8503bdba-7888-4731-862a-236c6de3b339
Source identifiers:
226974
Local pid:
pubs:226974

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