Journal article
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
- Abstract:
-
Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD+ to deacetylate proteins, yieldingO-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to bind ADP-ribose derivatives, which diverged through evolution to support many different protein functions and pathways. The observation that some sirtuins and macrodomains are physically linked as fusi...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 286
- Issue:
- 15
- Pages:
- 13261-13271
- Publication date:
- 2011-01-01
- Acceptance date:
- 2011-01-12
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:115709
- UUID:
-
uuid:8501231c-91a8-4f8b-9b8d-eec3e6376784
- Local pid:
- pubs:115709
- Source identifiers:
-
115709
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2011
- Notes:
- © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record