Journal article
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
- Abstract:
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Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD+ to deacetylate proteins, yieldingO-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to bind ADP-ribose derivatives, which diverged through evolution to support many different protein functions and pathways. The observation that some sirtuins and macrodomains are physically linked as fusi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1074/jbc.m110.206771
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Funding
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Journal:
- Journal of Biological Chemistry More from this journal
- Volume:
- 286
- Issue:
- 15
- Pages:
- 13261-13271
- Publication date:
- 2011-01-01
- Acceptance date:
- 2011-01-12
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:115709
- UUID:
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uuid:8501231c-91a8-4f8b-9b8d-eec3e6376784
- Local pid:
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pubs:115709
- Source identifiers:
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115709
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2011
- Notes:
- © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A.
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