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Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering.

Abstract:

SIGNIFICANCE: Endothelial dysfunction and the imbalance between nitric oxide (NO) and reactive oxygen species production in the vascular endothelium are important early steps in atherogenesis, a major socioeconomic health problem. Statins have well-established roles in primary and secondary prevention of cardiovascular disease (CVD), due to both their lipid-lowering capacity and their pleiotropic properties. It is therefore important to understand the mechanisms by which statins can modify en...

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Publication status:
Published

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Publisher copy:
10.1089/ars.2013.5430

Authors


Margaritis, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Antoniades, C More by this author
Journal:
Antioxidants and redox signaling
Volume:
20
Issue:
8
Pages:
1198-1215
Publication date:
2014-03-05
DOI:
EISSN:
1557-7716
ISSN:
1523-0864
URN:
uuid:84fa9c9d-2de7-4278-b212-3c2eb26cc559
Source identifiers:
434185
Local pid:
pubs:434185

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