The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.

Journal article

OBJECTIVE: To determine the pharmacokinetic properties of artemether and lumefantrine (AL) in pregnant women with recrudescent uncomplicated multi-drug resistant falciparum malaria. METHODS: Pregnant women who had recurrence of parasitaemia following 7 days supervised quinine treatment were treated with AL. Serial blood samples were taken over a 7-day period, and pharmacokinetic parameters were estimated. For lumefantrine, these data were compared in a population pharmacokinetic model with d...

Expand abstract

Authors: Mcgready, R; Stepniewska, K; Lindegardh, N; Ashley, E; La, Y

• Publication status: Published
• Journal: European journal of clinical pharmacology
• Volume: 62
• Issue: 12
• Pages: 1021-1031
• Publication date: 2006-12-01
• DOI: 10.1007/s00228-006-0199-7
• EISSN: 1432-1041
• ISSN: 0031-6970
• Language: English
• Keywords: Tablets; Adult; Malaria, Falciparum; Drug Administration Schedule; Remission Induction; Half-Life; Pregnancy; Female; Pregnancy Trimester, Third; Sesquiterpenes; Follow-Up Studies; Recurrence; Humans; Thailand; Adolescent; Pregnancy Outcome; Pregnancy Trimester, Second; Ethanolamines; Antimalarials; Fluorenes; Male; Area Under Curve; Artemisinins