Immunisation with recombinant modified vaccinia virus Ankara expressing HIV-1 gag in HIV-1-infected subjects stimulates broad functional CD4+ T cell responses.

Journal article

Virus-specific CD4+ T cells with IL-2-secreting and/or proliferative capacity are detected readily in HIV-1-infected long-term nonprogressors and rarely in persons with untreated progressive infection. The contribution of these cells to viraemia control is uncertain, but this question might be addressed in clinical therapeutic vaccination studies. However, the quality of T helper responses induced by currently available HIV-1 vaccine candidates has not been explored in depth. We determined th...

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Authors: Ondondo, B; Yang, H; Dong, T; di Gleria, K; Suttill, A

• Publication status: Published
• Journal: European journal of immunology
• Volume: 36
• Issue: 10
• Pages: 2585-2594
• Publication date: 2006-10-01
• DOI: 10.1002/eji.200636508
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Interleukin-2; env Gene Products, Human Immunodeficiency Virus; HIV Infections; Amino Acid Sequence; HIV Core Protein p24; Epitopes, T-Lymphocyte; CD4-Positive T-Lymphocytes; Gene Products, gag; HIV-1; Antiretroviral Therapy, Highly Active; AIDS Vaccines; Vaccines, DNA; Vaccinia virus; Molecular Sequence Data; Interferon-gamma; Humans; Acquired Immunodeficiency Syndrome; Peptide Fragments