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Molecular mechanisms of cytoadherence in malaria

Abstract:

Microbial pathosens subvert host adhesion molecules to dissemi-nate or to enter host cells to promote their own survival. One such subversion is the cytoadherence of Plasmodium falciparum-infected erythrocytes (IRBC) to vascular endothelium, which protects the parasite from being removed by the spleen. The process results in microcirculatory obstruction and subsequent hypoxia, metabolic disturbances, and multiorgan failure, which are detrimental to the host. Understanding the molecular events...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
American Journal of Physiology
Volume:
276
Issue:
6 PART 1
Publication date:
1999-01-01
ISSN:
0002-9513
Source identifiers:
80066
Language:
English
Keywords:
Pubs id:
pubs:80066
UUID:
uuid:84d42330-1bc1-410b-bb69-4c142493f214
Local pid:
pubs:80066
Deposit date:
2013-02-20

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