Label-free sub-picomolar protein detection with field-effect transistors.

Journal article

Proteins mediate the bulk of biological activity and are powerfully assayed in the diagnosis of diseases. Protein detection relies largely on antibodies, which have significant technical limitations especially when immobilized on two-dimensional surfaces. Here, we report the integration of peptide aptamers with extended gate metal-oxide-semiconductor field-effect transistors (MOSFETs) to achieve label-free sub-picomolar target protein detection. Specifically, peptide aptamers that recognize h...

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Authors: Estrela, P; Paul, D; Song, Q; Stadler, L; Wang, L

• Publication status: Published
• Journal: Analytical chemistry
• Volume: 82
• Issue: 9
• Pages: 3531-3536
• Publication date: 2010-05-01
• DOI: 10.1021/ac902554v
• EISSN: 1520-6882
• ISSN: 0003-2700
• Language: English
• Keywords: Cyclin-Dependent Kinase 2; Transistors, Electronic; Humans; Biosensing Techniques; Proteins; Spectroscopy, Fourier Transform Infrared