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Thesis

Intracellular delivery of radioimmunoconjugates that target the cancer testis antigen, NY-ESO-1

Abstract:

Cancer testis antigens (CTA) represent attractive targets for targeted radiotherapy and imaging as their expression is restricted to cancer and germ cells. NY-ESO-1, a member of the CTA family, is highly immunogenic and expressed in multiple tumor types including carcinoma of bladder, liver lung. The aim of this study was to develop radioimmunoconjugates (RIC) to target NY-ESO-1 protein in cancer cells. Anti-NY-ESO-1 antibodies were modified by addition of DTPA for 111In-labelling or, in t...

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Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Medical Sciences Division - Medical Oncology

Contributors

Role:
Supervisor
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Funding agency for:
Hin Lun Chu
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:84c830c4-c216-4b2c-8383-e1119d77c295
Local pid:
ora:11522

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