Journal article
Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells
- Abstract:
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Sirtuin-1 (SIRT1) and SIRT6, NAD+-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of the lung and associated with increased oxidative stress. Here, we show that oxidative stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not the related miR-34b/c, with concomitant reduction of SIRT1/-6 in bronchial epithelial cells (...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 1.2MB)
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- Publisher copy:
- 10.1038/srep35871
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Issue:
- 1
- Pages:
- 35871
- Publication date:
- 2016-10-21
- Acceptance date:
- 2016-10-07
- DOI:
- EISSN:
-
2045-2322
- ISSN:
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2045-2322
- Pubs id:
-
pubs:826141
- URN:
-
uri:84be2554-0de5-4972-bd04-e1103d08cd79
- UUID:
-
uuid:84be2554-0de5-4972-bd04-e1103d08cd79
- Local pid:
- pubs:826141
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Baker et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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