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Journal article

Expanding chemical biology of 2-oxoglutarate oxygenases.

Abstract:
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
Publication status:
Published

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Publisher copy:
10.1038/nchembio0308-152

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nat Chem Biol
Volume:
4
Issue:
3
Pages:
152-156
Publication date:
2008-03-01
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Source identifiers:
34133
Language:
English
Keywords:
Pubs id:
pubs:34133
UUID:
uuid:84ba0fe2-4b55-41a6-8588-139a9dfcff8e
Local pid:
pubs:34133
Deposit date:
2012-12-19

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