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Journal article

Effectiveness analyses may underestimate protection of infants after group C meningococcal immunization

Abstract:

Background. Group C meningococcal conjugate-vaccine effectiveness in the United Kingdom declines from ~90% in the first year to 0% between 1 and 4 years after immunization in infants immunized at 2, 3, and 4 months of age and to 61% in toddlers given a single dose. Confidence intervals are wide, and the extent of protection is uncertain. Methods. Serum samples were obtained from children 3-5 years of age who were participants in a preschool booster-vaccine trial. Serum bacterial activity was ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1086/505077

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Institution:
"Children's Hospital Oakland Research Institute, Oakland, California"
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Institution:
"St. George's University of London, UK"
Department:
Vaccine Institute
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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Publisher:
University of Chicago Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
194
Issue:
2
Pages:
231-237
Publication date:
2006-07-05
DOI:
ISSN:
0022-1899
URN:
uuid:84b67169-71c5-48a5-8cef-c772c4c2fe96
Local pid:
ora:3050
Language:
English
Subjects:

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