Journal article
Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.
- Abstract:
-
The CCAAT enhancer binding protein alpha (C/EBPalpha) is an important myeloid tumor suppressor that is frequently mutated in human acute myeloid leukemia (AML). We have previously shown that mice homozygous for the E2F repression-deficient Cebpa(BRM2) allele develop nonfatal AML with long latency and incomplete penetrance, suggesting that accumulation of secondary mutations is necessary for disease progression. Here, we use SRS19-6-driven retroviral insertional mutagenesis to compare the phen...
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- Publisher copy:
- 10.1182/blood-2007-06-097790
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 111
- Issue:
- 8
- Pages:
- 4309-4321
- Publication date:
- 2008-04-01
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
324063
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:324063
- UUID:
-
uuid:84b504d1-67cc-4de2-ad4c-e4535e892b25
- Local pid:
- pubs:324063
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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