Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.

Hasemann, MS; Damgaard, I; Schuster, MB; Theilgaard-Mönch, K; Sørensen, AB; Mrsic, A; Krugers, T; Ylstra, B; Pedersen, FS; Nerlov, C; Porse, BT

Abstract:

The CCAAT enhancer binding protein alpha (C/EBPalpha) is an important myeloid tumor suppressor that is frequently mutated in human acute myeloid leukemia (AML). We have previously shown that mice homozygous for the E2F repression-deficient Cebpa(BRM2) allele develop nonfatal AML with long latency and incomplete penetrance, suggesting that accumulation of secondary mutations is necessary for disease progression. Here, we use SRS19-6-driven retroviral insertional mutagenesis to compare the phen...

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APA Style

Hasemann, M. S., Damgaard, I., Schuster, M. B., Theilgaard-Mönch, K., Sørensen, A. B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F. S., Nerlov, C., & Porse, B. T. (2008). Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Blood, 111(8), 4309–4321.

MLA Style

Hasemann, M. S., et al. “Mutation of C/EBPalpha Predisposes to the Development of Myeloid Leukemia in a Retroviral Insertional Mutagenesis Screen.” Blood, vol. 111, no. 8, Blood, 2008, pp. 4309–21.

Chicago Style

Hasemann, MS, I Damgaard, MB Schuster, K Theilgaard-Mönch, AB Sørensen, A Mrsic, T Krugers, et al. 2008. “Mutation of C/EBPalpha Predisposes to the Development of Myeloid Leukemia in a Retroviral Insertional Mutagenesis Screen.” Blood 111 (8): 4309–21.
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