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Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound.

Abstract:

Oncolytic viruses (OV) and ultrasound-enhanced drug delivery are powerful novel technologies. OV selectively self-amplify and kill cancer cells but their clinical use has been restricted by limited delivery from the bloodstream into the tumor. Ultrasound has been previously exploited for targeted release of OV in vivo, but its use to induce cavitation, microbubble oscillations, for enhanced OV tumor extravasation and delivery has not been previously reported. By identifying and optimizing the...

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Publication status:
Published

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Authors


Bazan-Peregrino, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Arvanitis, CD More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
169
Issue:
1-2
Pages:
40-47
Publication date:
2013-07-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:84b44e17-5cc9-4ca7-b688-77b0457ba994
Source identifiers:
394934
Local pid:
pubs:394934

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