Temporal transcriptomics suggest that twin-peaking genes reset the clock.
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the finer details of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissection (LCM) and RNA-seq over a 24 hr light / dark cycle. We show that 7-times more genes exhibited a classic sinusoidal expression signature than previously observed in the SCN. Another group of 76...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.9MB)
- Publisher copy:
- Copyright holder:
- Pembroke et al
- Copyright date:
Copyright © 2015, Pembroke et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record