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Temporal transcriptomics suggest that twin-peaking genes reset the clock.

Abstract:

The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the finer details of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissection (LCM) and RNA-seq over a 24 hr light / dark cycle. We show that 7-times more genes exhibited a classic sinusoidal expression signature than previously observed in the SCN. Another group of 76...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/elife.10518

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More from this funder
Funding agency for:
Davies, KE
More from this funder
Funding agency for:
Ponting, CP
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
4
Pages:
Article: e10518
Publication date:
2015-01-01
DOI:
EISSN:
2050-084X
URN:
uuid:84b1e758-d853-441d-9661-d263e30c11b7
Source identifiers:
586458
Local pid:
pubs:586458

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