Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner.

Journal article

Chemerin peptides represent a recently identified component of the endogenous anti-inflammatory network that act via the G protein-coupled receptor ChemR23. The role of the chemerin peptide/ChemR23 pathway in phagocytosis, the clearance of apoptotic cells (efferocytosis), and the resolution of inflammation is unknown. In this article, we report that low picomolar concentrations of the chemerin peptide chemerin15 (C15) enhance macrophage (MPhi) phagocytosis of microbial particles and apoptotic...

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Authors: Cash, J; Christian, A; Greaves, D

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 184
• Issue: 9
• Pages: 5315-5324
• Publication date: 2010-05-01
• DOI: 10.4049/jimmunol.0903378
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Protein-Tyrosine Kinases; Phagocytosis; Molecular Sequence Data; Humans; Chemotactic Factors; Macrophages, Peritoneal; Cells, Cultured; Neutrophils; Mice, Knockout; Intercellular Signaling Peptides and Proteins; Phenotype; Phagosomes; Amino Acid Sequence; Animals; Jurkat Cells; Peptides; Receptors, G-Protein-Coupled; Apoptosis; Mice, Inbred C57BL; Ligands; Intracellular Signaling Peptides and Proteins; Mice; Peptide Fragments