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Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease

Abstract:

Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD.Subthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III moto...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/mds.26759

Authors


Neumann, WJ More by this author
Schneider, GH More by this author
Brücke, C More by this author
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Medical Research Council More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Wiley Publisher's website
Journal:
Movement Disorders Journal website
Volume:
31
Issue:
11
Pages:
1748–1751
Publication date:
2016-08-22
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
Pubs id:
pubs:640471
URN:
uri:847d9fe6-2238-4d4e-b7fc-ffb9dd4774fd
UUID:
uuid:847d9fe6-2238-4d4e-b7fc-ffb9dd4774fd
Local pid:
pubs:640471

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