Inhibition of vasomotion in hippocampal cerebral arterioles during increases in neuronal activity.

Journal article

The activity of small arterioles, internal diameter 9.9 +/- 0.8 microm (SEM), was investigated in the CA1 region of hippocampal slices maintained in vitro at 34 degrees C. Under resting conditions, the vessels were quiescent. However, in the presence of the thromboxane A2 agonist U46619 (75-100 nM), rhythmic contractile activity (vasomotion, 1.1-9.9 min(-1), mean 4.1 +/- 0.7 min(-1) SEM) developed in the smooth muscle cells of the vessel walls. Electrical stimulation of the Schaffer collatera...

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Authors: Brown, L; Key, B; Lovick, T

• Publication status: Published
• Journal: Autonomic neuroscience : basic and clinical
• Volume: 95
• Issue: 1-2
• Pages: 137-140
• Publication date: 2002-01-01
• DOI: 10.1016/s1566-0702(01)00395-2
• EISSN: 1872-7484
• ISSN: 1566-0702
• Language: English
• Keywords: Rats, Wistar; Organ Culture Techniques; Cerebral Arteries; Action Potentials; Anesthetics, Local; Vasoconstriction; Neurons; Arterioles; Synaptic Transmission; Rats; Hippocampus; Male; Cerebrovascular Circulation; Tetrodotoxin; Electric Stimulation; Thromboxane A2; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Vasoconstrictor Agents; Animals