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Influence of perfusion on metabolism and matrix production by bovine articular chondrocytes in hydrogel scaffolds.

Abstract:

Articular cartilage has a limited capacity for self-repair after damage. Engineered cartilage is a promising treatment to replace or repair damaged tissue. The growth of engineered cartilage is sensitive to the extracellular culture environment. Chondrocytes were seeded into alginate beads and agarose scaffolds at 4 millions/mL, and the response to static and perfusion culture was examined over period of up to 12 days. For both types of scaffolds, the chondrocytes kept their differentiated mo...

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Publication status:
Published

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Publisher copy:
10.1002/bit.20818

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Journal:
Biotechnology and bioengineering
Volume:
93
Issue:
6
Pages:
1103-1111
Publication date:
2006-04-05
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
URN:
uuid:8463f662-f39f-496e-8338-d89f93773e86
Source identifiers:
62049
Local pid:
pubs:62049

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