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The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.

Abstract:

The macrophage-specific antigen F4/80 has been localized in mouse lymphoid and hematopoietic tissue and skin using immunoperoxidase staining. The antigen permits identification of early mononuclear phagocyte precursors in the bone marrow, and is present also on larger cells forming the center of hematopoietic islands and lining vascular sinuses. In thymus F4/80+ cells are numerous in both cortex and medulla and are particularly concentrated around the corticomedullary region. In spleen, lymph...

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Publication status:
Published

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Publisher copy:
10.1084/jem.158.5.1522

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
158
Issue:
5
Pages:
1522-1536
Publication date:
1983-11-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:8463b884-1290-48b3-bd5f-66c07840f82b
Source identifiers:
31234
Local pid:
pubs:31234

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