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Bioluminescence Resonance Energy Transfer 2 (BRET2)‐based RAS biosensors to characterize RAS inhibitors

Abstract:

Protein‐protein interactions (PPIs) are principle biological processes that control normal cell growth, differentiation, and homeostasis but are also crucial in diseases such as malignancy, neuropathy, and infection. Despite the importance of PPIs in biology, this target class has been very challenging to convert to therapeutics. In the last decade, much progress has been made in the inhibition of PPIs involved in diseases, but many remain difficult such as RAS‐effector interactions in cancer...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-4982-2609
Publisher:
Wiley Publisher's website
Journal:
Current Protocols in Cell Biology Journal website
Volume:
83
Issue:
1
Article number:
e83
Publication date:
2019-02-15
Acceptance date:
2019-01-27
DOI:
EISSN:
1934-2616
ISSN:
1934-2500
Pmid:
30768855
Pubs id:
pubs:974955
UUID:
uuid:845a6c07-932f-4bc2-a63f-62e68c5980c2
Source identifiers:
974955
Local pid:
pubs:974955

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