Journal article
Bioluminescence Resonance Energy Transfer 2 (BRET2)‐based RAS biosensors to characterize RAS inhibitors
- Abstract:
-
Protein‐protein interactions (PPIs) are principle biological processes that control normal cell growth, differentiation, and homeostasis but are also crucial in diseases such as malignancy, neuropathy, and infection. Despite the importance of PPIs in biology, this target class has been very challenging to convert to therapeutics. In the last decade, much progress has been made in the inhibition of PPIs involved in diseases, but many remain difficult such as RAS‐effector interactions in cancer...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, 578.2KB)
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- Publisher copy:
- 10.1002/cpcb.83
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Current Protocols in Cell Biology Journal website
- Volume:
- 83
- Issue:
- 1
- Article number:
- e83
- Publication date:
- 2019-02-15
- Acceptance date:
- 2019-01-27
- DOI:
- EISSN:
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1934-2616
- ISSN:
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1934-2500
- Pmid:
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30768855
- Source identifiers:
-
974955
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:974955
- UUID:
-
uuid:845a6c07-932f-4bc2-a63f-62e68c5980c2
- Local pid:
- pubs:974955
- Deposit date:
- 2019-03-13
Terms of use
- Copyright holder:
- John Wiley & Sons, Inc.
- Copyright date:
- 2019
- Rights statement:
- © 2019 John Wiley & Sons, Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/cpcb.83
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