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Journal article

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.

Abstract:

Spinal muscular atrophy (SMA) is characterized by the selective loss of spinal motor neurons owing to reduced levels of survival motor neuron (Smn) protein. In addition to its well-established role in assembling constituents of the spliceosome, diverse cellular functions have been proposed for Smn, but the reason why low levels of this widely expressed protein result in selective motor neuron pathology is still debated. In longitudinal studies of exon-level changes in SMA mouse model tissues,...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddt477

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Human molecular genetics
Volume:
23
Issue:
4
Pages:
855-869
Publication date:
2014-02-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
430812
Language:
English
Keywords:
Pubs id:
pubs:430812
UUID:
uuid:845479b6-8bc0-4b98-b65b-26067e35fd20
Local pid:
pubs:430812
Deposit date:
2013-11-16

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