Journal article icon

Journal article

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.

Abstract:

Spinal muscular atrophy (SMA) is characterized by the selective loss of spinal motor neurons owing to reduced levels of survival motor neuron (Smn) protein. In addition to its well-established role in assembling constituents of the spliceosome, diverse cellular functions have been proposed for Smn, but the reason why low levels of this widely expressed protein result in selective motor neuron pathology is still debated. In longitudinal studies of exon-level changes in SMA mouse model tissues,...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/ddt477

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Expand authors...
Journal:
Human molecular genetics
Volume:
23
Issue:
4
Pages:
855-869
Publication date:
2014-02-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:845479b6-8bc0-4b98-b65b-26067e35fd20
Source identifiers:
430812
Local pid:
pubs:430812

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP