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Renal cells activate the platelet receptor CLEC-2 through podoplanin

Abstract:

We have recently shown that the C-type lectin-like receptor, CLEC-2, is expressed on platelets and that it mediates powerful platelet aggregation by the snake venom toxin rhodocytin. In addition, we have provided indirect evidence for an endogenous ligand for CLEC-2 in renal cells expressing HIV-1. This putative ligand facilitates transmission of HIV through its incorporation into the viral envelope and binding to CLEC-2 on platelets. The aim of the present study was to identify the ligand on...

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Publisher copy:
10.1042/BJ20071216

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Journal:
Biochemical Journal
Volume:
411
Issue:
1
Pages:
133-140
Publication date:
2008-04-01
DOI:
ISSN:
0264-6021
URN:
uuid:845173e2-49f8-4947-9490-83daadc58e0e
Source identifiers:
102562
Local pid:
pubs:102562

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