Journal article icon

Journal article

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Abstract:

OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inh...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.2337/db09-0525

Authors


Expand authors...
Journal:
Diabetes
Volume:
58
Issue:
11
Pages:
2506-2515
Publication date:
2009-11-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:8440690d-34ee-4951-8b48-b1c14c8f5761
Source identifiers:
482083
Local pid:
pubs:482083

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP