The systemic fibrinolytic activity of intrapleural streptokinase.

Journal article

Intrapleural fibrinolytics probably improve the drainage of loculated pleural effusions and empyemas. Studies of crude indices of systemic coagulation suggest this effect is accompanied by little systemic fibrinolysis, but few studies have assessed this in detail. This study examines the systemic fibrinolytic activity of two intrapleural streptokinase (IPSK) regimes in detail. Eight patients received a single dose of 250,000 IU IPSK, and a further eight received serial doses of 250,000 IU IPS...

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Authors: Davies, C; Lok, S; Davies, R

• Journal: American journal of respiratory and critical care medicine
• Volume: 157
• Issue: 1
• Pages: 328-330
• Publication date: 1998-01-01
• DOI: 10.1164/ajrccm.157.1.97-03094
• EISSN: 1535-4970
• ISSN: 1073-449X
• Language: English
• Keywords: Drug Monitoring; Empyema, Pleural; Pleurodesis; Humans; Partial Thromboplastin Time; Thrombin Time; Adult; Middle Aged; Aged; Prothrombin Time; Fibrinolysis; Female; Male; Aged, 80 and over; Fibrinolytic Agents; Streptokinase; Pleural Effusion; Drainage