Journal article icon

Journal article

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.

Abstract:

DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear. Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (HR) repair and suppressing extensive LOH and chromosomal rearrangements in response to a DSB. Accordingly, deletion of Rad3(ATR), Rad26ATRIP, Crb2(53BP1) or Cdc25 overexpression leads to reduced HR...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gku190

Authors


Blaikley, EJ More by this author
Tinline-Purvis, H More by this author
Kasparek, TR More by this author
Marguerat, S More by this author
Expand authors...
Publisher:
Oxford University Press
Journal:
Nucleic acids research
Volume:
42
Issue:
9
Pages:
5644-5656
Publication date:
2014-05-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:843a00d3-edc3-4152-85d6-ba8adbcc4d58
Source identifiers:
457727
Local pid:
pubs:457727

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP