Journal article
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
- Abstract:
-
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear. Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (HR) repair and suppressing extensive LOH and chromosomal rearrangements in response to a DSB. Accordingly, deletion of Rad3(ATR), Rad26ATRIP, Crb2(53BP1) or Cdc25 overexpression leads to reduced HR...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/nar/gku190
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Nucleic acids research
- Volume:
- 42
- Issue:
- 9
- Pages:
- 5644-5656
- Publication date:
- 2014-05-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:843a00d3-edc3-4152-85d6-ba8adbcc4d58
- Source identifiers:
-
457727
- Local pid:
- pubs:457727
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2014
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