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Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas

Abstract:

The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole-organ and isolated-islet transplantation outcomes. Post-mortem changes have also hampered accurate interpretation of ante-mortem pancreatic pathology. A rigorous histological scoring system accurately quantifying ischaemia is required to experimentally evaluate innovations in organ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cjp2.185

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Role:
Author
ORCID:
0000-0003-3285-3991
Publisher:
Wiley Publisher's website
Journal:
The Journal of Pathology: Clinical Research Journal website
Volume:
7
Issue:
2
Pages:
173-187
Publication date:
2020-11-22
Acceptance date:
2020-09-28
DOI:
EISSN:
2056-4538
Pmid:
33225596
Language:
English
Keywords:
Pubs id:
1149045
Local pid:
pubs:1149045
Deposit date:
2020-12-18

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