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Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria.

Abstract:

Serum antibodies from 1071 people in two Kenyan villages were assayed using eight different recombinant Apical Membrane Antigen 1 (AMA1) protein constructs to investigate their role in naturally acquired immunity. In both communities, antibodies against the full-length ectodomain (both FVO and 3D7 allele constructs) prior to a malaria transmission season were significantly associated with protection from malaria in the following 6 months, even after adjusting for age and antibody reactivity t...

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Publication status:
Published

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Authors


Polley, SD More by this author
Kocken, CH More by this author
Thomas, AW More by this author
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Journal:
Vaccine
Volume:
23
Issue:
5
Pages:
718-728
Publication date:
2004-12-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:842dea03-2289-4681-88a7-d901cba43d60
Source identifiers:
39278
Local pid:
pubs:39278

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