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Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.

Abstract:

We have prepared oligonucleotides containing the novel base analogue 2'-aminoethoxy,5-propargylamino-U in place of thymidine and examined their ability to form intermolecular and intramolecular triple helices by DNase I footprinting and thermal melting studies. The results were compared with those for oligonucleotides containing 5-propargylamino-dU and 2'-aminoethoxy-T. We find that the bis-substituted derivative produces a large increase in triplex stability, much greater than that produced ...

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Publication status:
Published

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Publisher copy:
10.1021/bi020164n

Authors


Sollogoub, M More by this author
Cuenoud, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Biochemistry
Volume:
41
Issue:
23
Pages:
7224-7231
Publication date:
2002-06-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:84198730-bf5b-4050-a9e9-1f31859f8035
Source identifiers:
277640
Local pid:
pubs:277640

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