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Journal article

The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C.

Abstract:

The vast majority of new human HLA class I alleles are formed by conversions between existing alleles of the same locus. A notable exception to this rule is HLA-B*4601 formed by replacement of residues 66-76 of the alpha 1 helix of B*1501 by the homologous segment of Cw*0102. This inter-locus recombination, which brings together characteristic elements of HLA-B and HLA-C structure, is shown here to influence function dramatically. Naturally processed peptides bound by B*4601 are distinct from...

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Publication status:
Published

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Publisher copy:
10.1084/jem.184.2.735

Authors


Barber, LD More by this author
Percival, L More by this author
Valiante, NM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
The Journal of experimental medicine
Volume:
184
Issue:
2
Pages:
735-740
Publication date:
1996-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:841665c0-d355-4e11-99c9-76e9e250d7de
Source identifiers:
58555
Local pid:
pubs:58555

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