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An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission.

Abstract:

Gametocytes are the sole Plasmodium parasite stages that infect mosquitoes; therefore development of functional gametes is required for malaria transmission. Flagellum assembly of the Plasmodium male gamete differs from that of most other eukaryotes in that it is intracytoplasmic but retains a key conserved feature: axonemes assemble from basal bodies. The centriole/basal body protein SAS-6 normally regulates assembly and duplication of these organelles and its depletion causes severe flagell...

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Publisher copy:
10.1111/cmi.12355

Authors


Marques, SR More by this author
Ramakrishnan, C More by this author
Carzaniga, R More by this author
Blagborough, AM More by this author
Delves, MJ More by this author
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Journal:
Cellular microbiology
Pages:
n/a-n/a
Publication date:
2014-08-05
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
URN:
uuid:840e120b-30fc-42fe-ae68-4a1150042198
Source identifiers:
482187
Local pid:
pubs:482187
Language:
English

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