B cell metabolism and autophagy in autoimmunity

Journal article : Review

Abstract:: B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen presentation, cytokine secretion, and the production of autoantibodies. During development and differentiation, B cells undergo drastic changes in their physiology. It is emerging that these are accompanied by equally significant shifts in metabolic phenotype, which may themselves also drive and enforce the functional properties of the cell. The dysfunction of B cells during autoimmunity is characterised by the breaching of tolerogenic checkpoints, and there is developing evidence that the metabolic state of B cells may contribute to this. Determining the metabolic phenotype of B cells in autoimmunity is an area of active study, and is important because intervention by metabolism-altering therapeutic approaches may represent an attractive treatment target.

Files:: Raza_and_Clarke_2021_B_cell_metabolism.pdf

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Language:: English
Keywords:: Autoimmunity

FFR

SLE - systemic lupus erythematosus

Metabolism

B cell

Autophagy

B cell development and differentiation
Subtype:: Review
Pubs id:: 1181446
Local pid:: pubs:1181446
Deposit date:: 2022-10-17

Copyright holder:: Raza and Clarke.
Rights statement:: © 2021 Raza and Clarke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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