Journal article
Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
- Abstract:
-
BACKGROUND: Treatment with statins improves clinical outcome, but the exact mechanisms of pleiotropic statin effects on vascular function in human atherosclerosis remain unclear. We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease. METHODS AND RESULTS: We first examined the association of statin treatment with vascular NO bioavailability and arterial superoxide (O(2)(·-)) in 492...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/circulationaha.110.985150
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Bibliographic Details
- Journal:
- Circulation
- Volume:
- 124
- Issue:
- 3
- Pages:
- 335-345
- Publication date:
- 2011-07-01
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Source identifiers:
-
163881
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:163881
- UUID:
-
uuid:83fd8059-c654-4057-9aca-cfd208c2ac57
- Local pid:
- pubs:163881
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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