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Journal article

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.

Abstract:

BACKGROUND: Treatment with statins improves clinical outcome, but the exact mechanisms of pleiotropic statin effects on vascular function in human atherosclerosis remain unclear. We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease. METHODS AND RESULTS: We first examined the association of statin treatment with vascular NO bioavailability and arterial superoxide (O(2)(·-)) in 492...

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Publication status:
Published

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Journal:
Circulation
Volume:
124
Issue:
3
Pages:
335-345
Publication date:
2011-07-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:83fd8059-c654-4057-9aca-cfd208c2ac57
Source identifiers:
163881
Local pid:
pubs:163881

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