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A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.

Abstract:

Human cultured mast cells, immunologically activated with immunoglobuin E (IgE)/anti-IgE, released a factor(s) that promoted chemotaxis of human CRTH2+ CD4+ T helper type 2 (Th2) lymphocytes. Mast cell supernatants collected at 20 min, 1 hr, 2 hr and 4 hr after activation caused a concentration-dependent increase in the migration of Th2 cells. The effect of submaximal dilutions of mast-cell-conditioned media was inhibited in a dose-dependent manner by ramatroban (IC50 = 96 nm), a dual antagon...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Townsend, ER More by this author
Pettipher, R More by this author
Journal:
Immunology
Volume:
119
Issue:
3
Pages:
362-368
Publication date:
2006-11-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:83fc2c4a-e838-4bde-b4bb-0022e3b735af
Source identifiers:
111595
Local pid:
pubs:111595

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