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Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

Abstract:

OBJECTIVE: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci. METHODS: We synthesized 7 MS GWAS. Each data set was imputed using HapMap phase II, and a per single nucleotide polymorphism (SNP) meta-analysis was performed across the 7 data sets. We explored RNA expression data using a quantitative trait analysis in peripheral blood mononuclear cells (PBMCs) of ...

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Publisher copy:
10.1002/ana.22609

Authors


Patsopoulos, NA More by this author
Esposito, F More by this author
Reischl, J More by this author
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Journal:
Annals of neurology
Volume:
70
Issue:
6
Pages:
897-912
Publication date:
2011-12-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:83f72ae5-a649-4544-b616-0c37aabc611a
Source identifiers:
245824
Local pid:
pubs:245824

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