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Journal article

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.

Abstract:

Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently poorly understood. Here we demonstrate a novel requirement for FGF signalling in the specification of aortic haemogenic endothelium. Our results demonstrate that FGF signalling n...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms6588

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Journal:
Nature communications
Volume:
5
Pages:
5588
Publication date:
2014-01-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Language:
English
Pubs id:
pubs:491751
UUID:
uuid:83e65fe1-7f50-4b77-a77d-19df9d35c425
Local pid:
pubs:491751
Source identifiers:
491751
Deposit date:
2014-12-19

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