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Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.

Abstract:

OBJECTIVE: To test whether the chronic relapsing arthritis induced by immunizing DBA/1 mice with homologous type II collagen is a valuable model for testing disease-modifying antiarthritic drugs. METHODS: Six-week-old male DBA/1 mice were immunized with murine type II collagen in Freund's complete adjuvant, resulting in a chronic relapsing polyarthritis in >80% of the mice 4 weeks after immunization. At the onset of clinical arthritis, mice were treated for 4 weeks with different treatment...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Arthritis and rheumatism
Volume:
44
Issue:
5
Pages:
1215-1224
Publication date:
2001-05-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:83e58c10-01c1-4cbe-b944-2c93c22475a2
Source identifiers:
224060
Local pid:
pubs:224060

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