- Abstract:
-
OBJECTIVE: To test whether the chronic relapsing arthritis induced by immunizing DBA/1 mice with homologous type II collagen is a valuable model for testing disease-modifying antiarthritic drugs. METHODS: Six-week-old male DBA/1 mice were immunized with murine type II collagen in Freund's complete adjuvant, resulting in a chronic relapsing polyarthritis in >80% of the mice 4 weeks after immunization. At the onset of clinical arthritis, mice were treated for 4 weeks with different treatment...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/1529-0131(200105)44:5<1215::aid-anr206>3.0.co;2-#
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- Journal:
- Arthritis and rheumatism
- Volume:
- 44
- Issue:
- 5
- Pages:
- 1215-1224
- Publication date:
- 2001-05-05
- DOI:
- EISSN:
-
1529-0131
- ISSN:
-
0004-3591
- URN:
-
uuid:83e58c10-01c1-4cbe-b944-2c93c22475a2
- Source identifiers:
-
224060
- Local pid:
- pubs:224060
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
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