Journal article
TNF Receptor 2 Signaling Prevents DNA Methylation at the Foxp3 Promoter and Prevents Pathogenic Conversion of Regulatory T Cells
- Abstract:
-
Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is associated with reduced Foxp3 expression, function, and loss of phenotypic stability. Previous studies have established the importance of TNF receptor 2 (TNFR2) in the generation and/or activation of Treg cells. In this study, we assess the importance of TNFR2 in healthy mice and under inflammatory conditions. Our findings reveal that, in health...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 116
- Issue:
- 43
- Pages:
- 21666-21672
- Publication date:
- 2019-10-09
- Acceptance date:
- 2019-10-09
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1111958
- Local pid:
- pubs:1111958
- Deposit date:
- 2020-06-12
Terms of use
- Copyright date:
- 2019
- Rights statement:
- © 2019
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