Journal article
Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates
- Abstract:
- The reduction of C(6)-acyl bicyclic tetramic acids has been achieved with complete diastereoselectivity via catalytic hydrogenation using PtO2. The resulting pyroglutamates had potent antibacterial and anticancer properties and will allow the preparation of simple mimics of pyroglutamate-containing natural products.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 709.9KB, Terms of use)
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- Publisher copy:
- 10.1039/c8ob00187a
Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic and Biomolecular Chemistry More from this journal
- Volume:
- 16
- Pages:
- 2705-2710
- Publication date:
- 2018-03-19
- Acceptance date:
- 2018-03-19
- DOI:
- EISSN:
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1477-0539
- ISSN:
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1477-0520
- Pmid:
-
29589033
Item Description
- Language:
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English
- Pubs id:
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pubs:832169
- UUID:
-
uuid:83e3301e-2784-4de6-889c-b9c29d7d12fb
- Local pid:
-
pubs:832169
- Source identifiers:
-
832169
- Deposit date:
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2018-04-13
Terms of use
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2018
- Notes:
- © The Royal Society of Chemistry 2018. This is the accepted manuscript version of the article. The final version is available online from Royal Society of Chemistry at: 10.1039/c8ob00187a
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